Bmal1^tm1.2Shbi
Targeted Allele Detail

Summary

• Symbol: Bmal1^tm1.2Shbi
• Name: basic helix-loop-helix ARNT like 1; targeted mutation 1.2, Shigeki Shimba
• MGI ID: MGI:5613363
• Synonyms: Bmal1^-
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^tm1.2Shbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin cassette with a 3' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 6 through 8. (J:177865)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 137 strains or lines available

References

• Original: J:177865 Shimba S, et al., Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One. 2011;6(9):e25231
• All: 8 reference(s)