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Pls1tm1Fri
Targeted Allele Detail
Nomenclature
Symbol: Pls1tm1Fri
Name: plastin 1 (I-isoform); targeted mutation 1, Francisco Rivero
MGI ID: MGI:5609592
Gene: Pls1  Location: Chr9:95752642-95845306 bp, - strand  Genetic Position: Chr9, 50.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216723
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaces the second exon of the gene, which contains the start codon. Northern blot analysis indicates expression of low amounts of mRNA of slightly smaller size in intestinal mucosa of homozygotes. Western blot analysis of small intestine lysates indicates absence of protein in homozygotes and further analysis with pan-fimbrin polyclonal antiserum does not find any truncated protein. (J:216723)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pls1 Mutation:  5 strains or lines available
References
Original:  J:216723 Grimm-Gunter EM, et al., Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Mol Biol Cell. 2009 May;20(10):2549-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory