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Atg3tm1Kmts
Targeted Allele Detail
Nomenclature
Symbol: Atg3tm1Kmts
Name: autophagy related 3; targeted mutation 1, Masaaki Komatsu
MGI ID: MGI:5609520
Gene: Atg3  Location: Chr16:44979192-45008901 bp, + strand  Genetic Position: Chr16, 29.45 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215884
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 10, which codes the active site cysteine. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:215884)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atg3 Mutation:  12 strains or lines available
References
Original:  J:215884 Sou YS, et al., The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008 Nov;19(11):4762-75
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory