Kdm6b^tm1Mag
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1Mag
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1, Terry Magnuson
• MGI ID: MGI:5609429
• Synonyms: Jmjd3^tm1Mag
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216722
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 13 and an FRT flanked neomycin selection cassette followed by a second loxP was inserted in intron 20. After successful targeting the selection cassette was excised by transient expression of flp recombinase. (J:216722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:216722 Shpargel KB, et al., KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014 Aug;10(8):e1004507
• All: 4 reference(s)