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Pdcd2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Pdcd2tm1c(EUCOMM)Wtsi
Name: programmed cell death 2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5609169
Synonyms: Pdcd2flox
Gene: Pdcd2  Location: Chr17:15739470-15747563 bp, - strand  Genetic Position: Chr17, 8.95 cM
Mutation
origin
Mutant Cell Line:  EPD0372_1_A09
Germline Transmission:  Earliest citation of germline transmission: J:213699
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe cassette is composed of from 5' to 3' an frt site, an En2 splice acceptor cassette containing a beta--galactosidase sequence, and loxP-flanked neomycin cassette, containing a frt site, inserted downstream of exon 1. A third loxP site was inserted downstream of exon 2. The critical exon is thus flanked by loxP sites. FLP mediated recombination removed the FRT-flanked lacZ and neo cassette leaving exon 2 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:155845, J:213699)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdcd2 Mutation:  12 strains or lines available
References
Original:  J:213699 Granier CJ, et al., Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Biol Open. 2014;3(9):821-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory