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Scn11atm1Gsk
Targeted Allele Detail
Nomenclature
Symbol: Scn11atm1Gsk
Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, GlaxoSmithKline
MGI ID: MGI:5608917
Gene: Scn11a  Location: Chr9:119753763-119825456 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216497
Parent Cell Line:  E14TG2aIV (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES/lacZpA cassette followed by a floxed neo cassette was inserted into the end of exon 5 resulting in the deletion of exons 6 and 7. (J:216497)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn11a Mutation:  52 strains or lines available
References
Original:  J:216497 Maingret F, et al., Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism. J Gen Physiol. 2008 Mar;131(3):211-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory