Nfkb1^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb1^M1Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 1, Bruce Beutler
• MGI ID: MGI:5607766
• Synonyms: Finlay
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a T to A transversion at base pair 135,595,053 (v38) on chromosome 3, corresponding to base pair 96,495 in the GenBank genomic region NC_000069 encoding Nfkb1. This corresponds to nucleotide 2,253 in the NM_008689 mRNA sequence, in exon of 18 of 25 total exons, as well as to residue 1,765 in the ENSMUST00000164430 cDNA sequence, in exon 16 of 23 total exons. The mutation results in premature termination of the protein, instead of insertion of leucine (L), at amino acid position 584 (L584Ter). (J:216054)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 99 strains or lines available

References

• Original: J:216054 Wang KW, et al., Mutagenetix entry for Finlay. Updated on December 19, 2014. MGI Direct Data Submission. 2014
• All: 2 reference(s)