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Targeted Allele Detail
Symbol: Ptbp2tm1.1Dblk
Name: polypyrimidine tract binding protein 2; targeted mutation 1.1, Douglas Black
MGI ID: MGI:5607602
Synonyms: Ptbp2loxP
Gene: Ptbp2  Location: Chr3:119718741-119783799 bp, - strand  Genetic Position: Chr3, 52.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:207976
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked PGK-neomycin cassette and loxP site were introduced to intron 3 and a loxP site was placed in intron 4 via homologous recombination. The neomycin cassette was excised from resultant mice through crosses with a Flp recombinase-expressing strain, leaving exon 4 flanked by loxP sites. Diptheria toxin was also a component of the targeting vector, but was also excised. (J:101977, J:207976)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptbp2 Mutation:  41 strains or lines available
Original:  J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory