Tg(KRT14-Igk/OVA*/PDGFRB)6mSika
Transgene Detail

Summary

• Symbol: Tg(KRT14-Igk/OVA*/PDGFRB)6mSika
• Name: transgene insertion 6m, Stephen Katz
• MGI ID: MGI:5607302
• Synonyms: K14-mOVA
• Transgene: Tg(KRT14-Igk/OVA*/PDGFRB)6mSika Location: unknown
• Alliance: Tg(KRT14-Igk/OVA*/PDGFRB)6mSika page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Igk/OVA*/PDGFRB)6mSika expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  chicken

  OVAL (396058)

  human

  PDGFRB (5159)

  Pdgfrb

  (MGI:97531)

• Mutation details: The transgenic construct contains a 2.1kb human KRT14 promoter directing a fusion protein consisting of the murine immunoglobulin k chain V-J2-C signal peptide, a truncated membrane bound ovalbumin (mOVA) cDNA fragment (200-1167), and sequence encoding the transmembrane domain of human platelet-derived growth factor receptor (PDGFR). RT-PCR analysis demonstrated mOVA expression in skin, but not in brain, thymus, lymph nodes, heart, liver, spleen, kidney, intestine, skeletal muscles or esophagus. (J:90508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90508 Shibaki A, et al., Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice. J Invest Dermatol. 2004 Jul;123(1):109-15
• All: 2 reference(s)