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Transgene Detail
Symbol: Tg(KRT14-Igk/OVA*/PDGFRB)6mSika
Name: transgene insertion 6m, Stephen Katz
MGI ID: MGI:5607302
Synonyms: K14-mOVA
Transgene: Tg(KRT14-Igk/OVA*/PDGFRB)6mSika  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(KRT14-Igk/OVA*/PDGFRB)6mSika expresses 2 genes
Mutation detailsThe transgenic construct contains a 2.1kb human KRT14 promoter directing a fusion protein consisting of the murine immunoglobulin k chain V-J2-C signal peptide, a truncated membrane bound ovalbumin (mOVA) cDNA fragment (200-1167), and sequence encoding the transmembrane domain of human platelet-derived growth factor receptor (PDGFR). RT-PCR analysis demonstrated mOVA expression in skin, but not in brain, thymus, lymph nodes, heart, liver, spleen, kidney, intestine, skeletal muscles or esophagus. (J:90508)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:90508 Shibaki A, et al., Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice. J Invest Dermatol. 2004 Jul;123(1):109-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory