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Cd22m2Btlr
Chemically induced Allele Detail
Summary
Symbol: Cd22m2Btlr
Name: CD22 antigen; mutation 2, Bruce Beutler
MGI ID: MGI:5607164
Synonyms: crullers
Gene: Cd22  Location: Chr7:30564829-30579767 bp, - strand  Genetic Position: Chr7, 19.26 cM
Alliance: Cd22m2Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsThe crullers mutation is in Cd22: a T to C transition at base pair 30,869,883 (v38) on chromosome 7, or base pair 10,460 in the GenBank genomic region NC_000073. This corresponds to nucleotide 2,045 in the mRNA sequence NM_009845 within exon 8 of 14 total exons or nucleotide 2,170 in the mRNA sequence NM_001043317 in exon 10 of 16 total exons. The mutation results in a serine (S) to proline (P) substitution at position 603 (S603P) in both CD22 isoforms. (J:215821)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  63 strains or lines available
References
Original:  J:215821 Zeng M, et al., Mutagenetix entry for crullers. MGI Direct Data Submission. 2014;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory