Pten^tm3.1Ppp
Targeted Allele Detail

Summary

• Symbol: Pten^tm3.1Ppp
• Name: phosphatase and tensin homolog; targeted mutation 3.1, Pier Paolo Pandolfi
• MGI ID: MGI:5606180
• Synonyms: Pten^C124S, PTENC124S
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm3.1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214411
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitutions in exon 5 were introduced by homologous recombination to alter codon 124 from one encoding cysteine to encoding serine (Cys124Ser). An adjacent loxP-flanked neomycin selection cassette that was inserted into intron 5 was removed by cre-mediated recombination. (J:214411)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm3.1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 81 strains or lines available

References

• Original: J:214411 Papa A, et al., Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell. 2014 Apr 24;157(3):595-610
• All: 4 reference(s)