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Nkx2-5tm1.1Wtp
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-5tm1.1Wtp
Name: NK2 homeobox 5; targeted mutation 1.1, William T Pu
MGI ID: MGI:5606034
Synonyms: CVDC/B2B program mutation, Nkx2-5flbio
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185868
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a FLAG/bio epitope tag and a frt-flanked neomycin resistance (neo) cassette at the endogenous Nkx2-5 stop codon and upstream of the 3' UTR. FLP mediated recombination removed the FRT-flanked neo cassette. (J:185868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
References
Original:  J:185868 Schramm C, Information about alleles developed by members of the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory