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b2b386.2Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b386.2Clo
Name: Mutant line 386.2 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 386.2 Cecilia Lo
MGI ID: MGI:5605971
Synonyms: chibi
Gene: b2b386.2Clo  Location: unknown  
EFIC Summary

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b386Clo.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b386.2Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiovascular phenotype:
Interrupted aortic arch (IAA)

Non-cardiac phenotype: Micrognathia, cleft palate, hypoplastic thymus, malaligned sternal vertebra, as well as duplex and hydronephrotic kidneys

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Codes Code Description
1250 Interrupted aortic arch
2700 Abnormal aortic arch
4100 Skeletal, skin, muscle anomaly
4163 Micrognathia
4447 Hepatic malformation
4502 Hydronephrosis
4512 Renal malformation
4876 Cleft palate

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory