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Txlngtm1.2Star
Targeted Allele Detail
Nomenclature
Symbol: Txlngtm1.2Star
Name: taxilin gamma; targeted mutation 1.2, Rene St-Arnaud
MGI ID: MGI:5605561
Synonyms: Fiat-
Gene: Txlng  Location: ChrX:162778919-162829454 bp, - strand  Genetic Position: ChrX, 74.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208796
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 34 bp loxP sequence was inserted upstream from exon 1 and a 6.4 kb PGK-neo-HsvTK cassette flanked by two loxP sites was introduced within intron 1. The loxP-flanked selection cassette and exon 1 were removed via cre-mediated recombination. RT-qPCR confirmed reduced mRNA expression in heterozygous females. (J:208796)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txlng Mutation:  47 strains or lines available
References
Original:  J:208796 Hekmatnejad B, et al., Altered gene dosage confirms the genetic interaction between FIAT and alphaNAC. Gene. 2014 Apr 1;538(2):328-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory