Hprt1^{tm1(ACTB-Opa1)Lsc}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(ACTB-Opa1)Lsc}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Luca Scorrano
• MGI ID: MGI:5605470
• Synonyms: Opa1^tg
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(ACTB-Opa1)Lsc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214492
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(ACTB-Opa1)Lsc} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Opa1 (MGI:1921393)

• Mutation details: A transgene carrying mouse variant 1 Opa1 gene and human exon 1 of HPRT under the control of the human beta-actin promoter was targeted to the Hprt locus by homologous recombination. (J:214492)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:214492 Cogliati S, et al., Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013 Sep 26;155(1):160-71
• All: 7 reference(s)