Tg(PRL)30Greg
Transgene Detail

Summary

• Symbol: Tg(PRL)30Greg
• Name: transgene insertion 30, Karen Gregerson
• MGI ID: MGI:5604903
• Transgene: Tg(PRL)30Greg Location: unknown
• Alliance: Tg(PRL)30Greg page

Transgene origin

• Strain of Origin: C57BL/6J x DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PRL)30Greg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRL (5617)

  Prl	(MGI:97762)

• Mutation details: The bacterial artificial chromosome (BAC) RP11273G3 from the Childrens Hospital Oakland Research Institute contains the entire human PRL gene, including the pituitary and extrapituitarypromoters as well as 115 kbp upstream and 38 kbp downstream of the gene-encoding sequences. Purified DNA was used for pronuclear microinjection into fertilized C57Bl/6J X DBA2 hybrid mouse oocytes. Two founder lines were produced (BAC-h8 and BAC-h30). (J:204079)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:204079 Christensen HR, et al., Completely humanizing prolactin rescues infertility in prolactin knockout mice and leads to human prolactin expression in extrapituitary mouse tissues. Endocrinology. 2013 Dec;154(12):4777-89
• All: 1 reference(s)