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Targeted Allele Detail
Symbol: Esr2tm1.1Ksk
Name: estrogen receptor 2 (beta); targeted mutation 1.1, Kenneth S Korach
MGI ID: MGI:5604770
Synonyms: Ex3BERKO, Ex3betaERKO
Gene: Esr2  Location: Chr12:76167193-76224033 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Germline Transmission:  Earliest citation of germline transmission: J:198474
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette and exon 3 were subsequently removed from properly targeted mice by cre excision. (J:198474)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  28 strains or lines available
Original:  J:198474 Binder AK, et al., The absence of ER-beta results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles. Endocrinology. 2013 Jun;154(6):2174-87
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory