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Hand1tm4Abfi
Targeted Allele Detail
Nomenclature
Symbol: Hand1tm4Abfi
Name: heart and neural crest derivatives expressed 1; targeted mutation 4, Anthony B Firulli
MGI ID: MGI:5604131
Synonyms: Hand1stopfloxHand1T107;S109D, PO4+
Gene: Hand1  Location: Chr11:57828707-57832818 bp, - strand  Genetic Position: Chr11, 35.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214092
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Inducible)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsResidues T107 and S109 were replaced with aspartic acids. A Stop-flox cassette containing a neomycin resistance gene was also inserted downstream of the Hand1 transcriptional start site, but upstream of the Hand1-initiating methionine. Cre-excision of the stop cassette results in expression of the mutant. (J:214092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  3 strains or lines available
References
Original:  J:214092 Firulli BA, et al., Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory