Wwtr1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Wwtr1^{tm1c(EUCOMM)Wtsi}
• Name: WW domain containing transcription regulator 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5603602
• Synonyms: Taz floxed, Wwtr1 floxed
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^{tm1c(EUCOMM)Wtsi} page
• IMPC: Wwtr1 gene page

Mutation origin

• Mutant Cell Line: EPD0436_1_A08
• Germline Transmission: Earliest citation of germline transmission: J:236047
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: This conditional allele, in which exon 3 is flanked by loxP sequences, was derived from the knockout-first Wwtr1^{tm1a(EUCOMM)Wtsi} allele by flp recombinase-mediated excision of the lacZ reporter and the neomycin selection cassette. Cre recombinase expression will result in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:236047)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:236047 Gruber R, et al., YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016 Sep;151(3):526-39
• All: 8 reference(s)