Pitx3^tm1Jdr
Targeted Allele Detail

Summary

• Symbol: Pitx3^tm1Jdr
• Name: paired-like homeodomain transcription factor 3; targeted mutation 1, Jaques Drouin
• MGI ID: MGI:5603161
• Synonyms: Pitx3 flox
• Gene: Pitx3 Location: Chr19:46124124-46136765 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Pitx3^tm1Jdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213576
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: An iinsertion of the neomycin resistance gene flanked by FRT sites and LoxP sites upstream of the neo cassette and downstream of exon 3 was generated by homologous recomibination.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx3 Mutation: 22 strains or lines available

Notes

This allele is a hypomorph expressed as 50% of the wild-type allel.

References

• Original: J:122955 L'honore A, et al., Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol. 2007 Jul 15;307(2):421-33
• All: 3 reference(s)