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Tg(MECP2*R306C/EGFP)1Hzo
Transgene Detail
Nomenclature
Symbol: Tg(MECP2*R306C/EGFP)1Hzo
Name: transgene insertion 1, Huda Y Zoghbi
MGI ID: MGI:5588452
Synonyms: MECP2R306C-EGFPTg, R306G Tg
Transgene: Tg(MECP2*R306C/EGFP)1Hzo  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MECP2*R306C/EGFP)1Hzo expresses 1 gene
 
Mutation detailsA human PAC (PAC671D9) containing only the MECP2 locus and regulatory elements was modified to introduce a R306C (CGC to TCG) missense mutation in the transcriptional repression domain (TRD) of exon 4 and a C-terminal GFP tag. Expression of the transgene parallels that of endogenous MECP2 in the brain. (J:214143)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:214143 Heckman LD, et al., Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. Elife. 2014;3
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory