Insc^tm1.1Cayo
Targeted Allele Detail

Summary

• Symbol: Insc^tm1.1Cayo
• Name: INSC spindle orientation adaptor protein; targeted mutation 1.1, Michel Cayouette
• MGI ID: MGI:5588147
• Synonyms: mInsc^Flox
• Gene: Insc Location: Chr7:114342931-114449615 bp, + strand Genetic Position: Chr7, 60.23 cM
• Alliance: Insc^tm1.1Cayo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214064
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The Insc mutation had the FRT flanked neomycin selection cassette removed by crossing to a FLP expressing line, leaving a loxP site in the intron between exons 1b and 2 and a second loxP site after the stop codon of exon 13, followed by an IRES-tau-EGFP reporter (J:214064)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insc Mutation: 28 strains or lines available

References

• Original: J:214064 Tarchini B, et al., A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell. 2013 Oct 14;27(1):88-102
• All: 1 reference(s)