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S1pr1tm3.1(tTA,-Arrb2)Rlp
Targeted Allele Detail
Nomenclature
Symbol: S1pr1tm3.1(tTA,-Arrb2)Rlp
Name: sphingosine-1-phosphate receptor 1; targeted mutation 1, Richard L Proia
MGI ID: MGI:5588124
Synonyms: S1P1-beta-arrestin
Gene: S1pr1  Location: Chr3:115504082-115508704 bp, - strand  Genetic Position: Chr3, 50.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212772
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Transactivator)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed with two fusion proteins separated by an internal ribosome entry site (IRES). One fusion protein contains a tobacco etch virus (TEV) protease recognition sequence (tevs) fused to a tetracycline-regulated transactivator (tTA or "Tet-Off") sequence. The second contains a murine arrestin, beta 2 (Arrb2) gene fused to the TEV protease. This construct was inserted at the 3 end of exon 2 of the sphingosine-1-phosphate receptor 1 (S1pr1) gene and was followed by a polyadenylation sequence and a loxP-flanked neomycin (neo) resistance cassette. Cre-mediated recombination removed the selection cassette. (J:212772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:  20 strains or lines available
References
Original:  J:212772 Kono M, et al., Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest. 2014 May 1;124(5):2076-86
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory