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Kmt2dtm1.1Kaig
Targeted Allele Detail
Nomenclature
Symbol: Kmt2dtm1.1Kaig
Name: lysine (K)-specific methyltransferase 2D; targeted mutation 1.1, Kai Ge
MGI ID: MGI:5585624
Synonyms: Mll4f
Gene: Kmt2d  Location: Chr15:98831669-98871204 bp, - strand  Genetic Position: Chr15, 54.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207891
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 16. An FRT-flanked neomycin resistance cassette with a 3 loxP site was inserted downstream of exon 19. Flp-mediated recombination removed the selection cassette and left exons 16 through 19 floxed. (J:207891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kmt2d Mutation:  110 strains or lines available
References
Original:  J:207891 Lee JE, et al., H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013;2:e01503
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory