Hprt1^{tm1(CAG-NPM1*)Pgp}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-NPM1*)Pgp}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Pier Giuseppe Pelicci
• MGI ID: MGI:5585588
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-NPM1*)Pgp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The cDNA of the most frequent mutation of NPM1, mutA, under the control of the pCAG promoter was inserted into the Hprt locus. A stop cassette flanked by loxP sites between the promoter and the cDNA was added, allowing for the conditional expression of the mutant gene upon cre-mediated recombination. (J:202794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:202794 Mallardo M, et al., NPMc+ and FLT3_ITD mutations cooperate in inducing acute leukaemia in a novel mouse model. Leukemia. 2013 Nov;27(11):2248-51
• All: 1 reference(s)