Tg(FXN)Y47Pook
Transgene Detail

Summary

• Symbol: Tg(FXN)Y47Pook
• Name: transgene insertion Y47, Mark A Pook
• MGI ID: MGI:5585461
• Synonyms: Y47
• Transgene: Tg(FXN)Y47Pook Location: unknown
• Alliance: Tg(FXN)Y47Pook page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FXN)Y47Pook expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FXN (2395)

  Fxn	(MGI:1096879)

• Mutation details: The transgene construct consists of a 370 kbp YAC (Y37FA12) that includes the entire human FXN gene with nine GAA repeats [(GAA)>9<] at the mutation locus within intron 1 of FXN. The GAA repeat expansion was not further modified. Founder line Y47 was established and contains a single copy integration of the transgene. (J:213628)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:213628 Pook MA, et al., Rescue of the Friedreich's ataxia knockout mouse by human YAC transgenesis. Neurogenetics. 2001 Oct;3(4):185-93
• All: 12 reference(s)