Slc8b1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc8b1^em1(IMPC)J
• Name: solute carrier family 8 (sodium/lithium/calcium exchanger), member B1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5584295
• Synonyms: Slc8b1^em1J
• Gene: Slc8b1 Location: Chr5:120649233-120672089 bp, + strand Genetic Position: Chr5, 60.63 cM
• Alliance: Slc8b1^em1(IMPC)J page
• IMPC: Slc8b1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele from project Slc8b1-5951J-2322 was generated at The Jackson Laboratory by injecting Cas9 RNA and an 18-mer guide sequence ATACTGGAGACGGCGTCT, which resulted in a 13 bp deletion AGACGGCGTCTGG in exon 2 beginning at Chromosome 5 positive strand position 120,513,241 bp (GRCm38), which is predicted to cause amino acid sequence changes after residue 21 and an early truncation 33 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc8b1 Mutation: 43 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 6 reference(s)