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Tg(Neurod1-cre/ERT2)M1Fcal
Transgene Detail
Nomenclature
Symbol: Tg(Neurod1-cre/ERT2)M1Fcal
Name: transgene insertion M1, Federico Calegari
MGI ID: MGI:5582823
Synonyms: Neurod1-CreERT2
Transgene: Tg(Neurod1-cre/ERT2)M1Fcal  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6JOlaHsd
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsBacterial artificial chromosome (BAC) library (Source BioScience) was used to obtain a 160 kb BAC (BMQ-305H2) containing the entire mouse Neurod1 gene. This BAC was modified to replace the coding region with a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by a frt-flanked neomycin (neo) selection cassette. Four lines were generated: L (low expression), M1 (intermediate expression), M2, H (high expression). This is a representative record for all lines. Transgene expression patterns are consistent with endogenous gene expression. (J:213056)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurod1     Summary of all recombinase alleles driven by Neurod1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:213056 Aprea J, et al., Generation and characterization of Neurod1-CreER(T2) mouse lines for the study of embryonic and adult neurogenesis. Genesis. 2014 Oct;52(10):870-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory