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Targeted Allele Detail
Symbol: Nkx2-5tm1.1Pash
Name: NK2 homeobox 5; targeted mutation 1.1, Mohammad Pashmforoush
MGI ID: MGI:5582820
Synonyms: Nkx2-5Flag
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  LSW1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a single loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, upstream of exon 2 of the gene. A 3X Flag sequence and a second loxP site were inserted into exon 2, upstream of the Nkx2-5 stop codon. FLP mediated recombination removed the FRT-flanked neo cassette. (J:101977)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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