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Shcbp1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Shcbp1tm1c(EUCOMM)Wtsi
Name: Shc SH2-domain binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5582589
Synonyms: Shcbp1FL
Gene: Shcbp1  Location: Chr8:4785976-4829567 bp, - strand  Genetic Position: Chr8, 2.09 cM, cytoband A1.2
Mutation
origin
Mutant Cell Line:  EPD0592_2_A06
Germline Transmission:  Earliest citation of germline transmission: J:212898
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 4750268 of Chromosome 8 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 4748418. The critical exon(s) are thus flanked by loxP sites. The lacZ and neomycin segments were excised with germline Actin-Flp recombinase, leaving exons 4 and 6 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:155845, J:212898)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shcbp1 Mutation:  26 strains or lines available
References
Original:  J:212898 Buckley MW, et al., Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLoS One. 2014;9(8):e105576
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory