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Tg(H2-K-IL6)2Srj
Transgene Detail
Nomenclature
Symbol: Tg(H2-K-IL6)2Srj
Name: transgene insertion 2, Stefan Rose-John
MGI ID: MGI:5582513
Synonyms: vIL-6tg2
Transgene: Tg(H2-K-IL6)2Srj  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe MHC class I promoter H2K drives the expression of the HHV-8 viral IL6 with a C-terminal MYC tag predominantly in hematopoietic organs and lymphocytes. Two lines were established, 1 and 2. (J:185153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Multicentric Castleman Disease, Plasma-cell type J:185153
References
Original:  J:185153 Suthaus J, et al., HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood. 2012 May 31;119(22):5173-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory