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Mafbtm1.2Good
Targeted Allele Detail
Nomenclature
Symbol: Mafbtm1.2Good
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian); targeted mutation 1.2, Lisa Goodrich
MGI ID: MGI:5581668
Gene: Mafb  Location: Chr2:160363703-160367065 bp, - strand  Genetic Position: Chr2, 80.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207904
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe single coding exon was flanked with loxP sites. An FRT-flanked neomycin resistance cassette was inserted downstream of the coding exon. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the coding exon. Western blot analysis confirmed the absence of protein expression in E16.5 embryos. (J:207904)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mafb Mutation:  10 strains or lines available
References
Original:  J:207904 Yu WM, et al., A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013;2:e01341
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory