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Crhm1H
Chemically induced Allele Detail
Nomenclature
Symbol: Crhm1H
Name: corticotropin releasing hormone; mutation 1, Harwell
MGI ID: MGI:5578654
Synonyms: Crh-120
Gene: Crh  Location: Chr3:19693401-19695396 bp, - strand  Genetic Position: Chr3, 5.75 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Applicable)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a T to C point mutation at -120 bp with reference to a transcription start (NM_205769) at the consensus sequence of a caudal-type homeobox response element (CDXARE). (J:208708)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crh Mutation:  15 strains or lines available
References
Original:  J:208708 Bentley L, et al., An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology. 2014 Mar;155(3):908-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory