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Mgat4btm1.1Jxm
Targeted Allele Detail
Nomenclature
Symbol: Mgat4btm1.1Jxm
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B; targeted mutation 1.1, Jamey Marth
MGI ID: MGI:5578604
Synonyms: GnT-IVb deficient, Mgat4b delta, Mgat4b type 1
Gene: Mgat4b  Location: Chr11:50225335-50235103 bp, + strand  Genetic Position: Chr11, 30.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212313
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette downstream of exons 2, 3, and 4, and a loxP site upstream of the exons. Cre-mediated recombination removed the neo cassette and exons 2-4 leaving a residual loxP site. Removal of exons 2-4 causes a frameshift at the junction of exon 1 and 5, generating a new translational termination codon that results in a truncated protein lacking the catalytic domain. (J:212313)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mgat4b Mutation:  22 strains or lines available
References
Original:  J:212313 Takamatsu S, et al., Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Glycobiology. 2010 Jan;20(4):485-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory