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Transgene Detail
Symbol: Tg(HSV-Hoxd4)70Cka
Name: transgene insertion 70, Claudia Kappen
MGI ID: MGI:5578562
Synonyms: IE-Hoxd-4
Transgene: Tg(HSV-Hoxd4)70Cka  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(HSV-Hoxd4)70Cka expresses 1 gene
Mutation detailsThe transresponder transgene contains mouse Hoxd4 cDNA under the control of the VP-16 responsive HSV immediate early (IE) promoter. A c-myc (Myc) epitope tag and SV40 poly-A sequence is inserted at the 3' end of the coding region. Transgene expression is activated when a transresponder mouse is combined with a transactivator mouse carrying the viral coactivator VP16 under the control of a promoter of interest. Expression is limited to regions in the mouse embryo where VP16 is present. (J:48458)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:48458 Rundle CH, et al., Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system. Biochim Biophys Acta. 1998 Jun 16;1398(2):164-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory