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Lamb2npht
Chemically induced Allele Detail
Nomenclature
Symbol: Lamb2npht
Name: laminin, beta 2; nephertiti
MGI ID: MGI:5578541
Gene: Lamb2  Location: Chr9:108479736-108490530 bp, + strand  Genetic Position: Chr9, 59.4 cM, cytoband F1
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a G to A point mutation that results in the amino acid substitution of tyrosine for cysteine at position 185 (C185Y).
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamb2 Mutation:  42 strains or lines available
References
Original:  J:208069 Bull KR, et al., Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol. 2014 May;233(1):18-26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory