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Tg(CMV-cat,-Rhoa)4-18Koba
Transgene Detail
Summary
Symbol: Tg(CMV-cat,-Rhoa)4-18Koba
Name: transgene insertion 4-18, Kazuto Kobayashi
MGI ID: MGI:5578311
Synonyms: CAT-RhoA DN/4-18
Transgene: Tg(CMV-cat,-Rhoa)4-18Koba  Location: unknown  
Alliance: Tg(CMV-cat,-Rhoa)4-18Koba page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-cat,-Rhoa)4-18Koba expresses 1 gene
 
Mutation detailsA 0.9 kb DNA fragment containing the cytomegalovirus early gene promoter was fused to the rabbit beta-globin second intron and chloramphenicol acetyltransferase (CAT) gene cassette connected to a polyadenylation signal, both ends of which were flanked by loxP sites. This was then followed by a 0.6 kb DNA fragment encoding a dominant-negative mutant for RhoA and a second polyadenylation signal. (J:100207)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100207 Kobayashi K, et al., Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci. 2004 Apr 7;24(14):3480-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory