Tg(CMV-cat,-Rhoa)4-18Koba
Transgene Detail

Summary

• Symbol: Tg(CMV-cat,-Rhoa)4-18Koba
• Name: transgene insertion 4-18, Kazuto Kobayashi
• MGI ID: MGI:5578311
• Synonyms: CAT-RhoA DN/4-18
• Transgene: Tg(CMV-cat,-Rhoa)4-18Koba Location: unknown
• Alliance: Tg(CMV-cat,-Rhoa)4-18Koba page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-cat,-Rhoa)4-18Koba expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rhoa (MGI:1096342)

• Mutation details: A 0.9 kb DNA fragment containing the cytomegalovirus early gene promoter was fused to the rabbit beta-globin second intron and chloramphenicol acetyltransferase (CAT) gene cassette connected to a polyadenylation signal, both ends of which were flanked by loxP sites. This was then followed by a 0.6 kb DNA fragment encoding a dominant-negative mutant for RhoA and a second polyadenylation signal. (J:100207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100207 Kobayashi K, et al., Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci. 2004 Apr 7;24(14):3480-8
• All: 4 reference(s)