Fzd6^tm2.1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd6^tm2.1Nat
• Name: frizzled class receptor 6; targeted mutation 2.1, Jeremy Nathans
• MGI ID: MGI:5578187
• Synonyms: Fz6 CKO
• Gene: Fzd6 Location: Chr15:38869673-38901587 bp, + strand
• Alliance: Fzd6^tm2.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228792
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 3 and 4 in order to flank exon 4 (the largest coding exon in the gene). A FRT-neo-FRT cassette that was used for positive selection was introduced adjacent to the loxP site in intron 3. FLP-mediated recombination removed the FRT-flanked neo cassette. (J:228792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd6 Mutation: 43 strains or lines available

References

• Original: J:228792 Chang H, et al., The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Dev Biol. 2016 Jan 1;409(1):181-93
• All: 2 reference(s)