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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm8(cre/Esr1*)Nat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutaion 8, Jeremy Nathans
MGI ID: MGI:5578185
Synonyms: R26 IMCM
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    by tamoxifen
Mutation:    Insertion
Mutation detailsThe targeting vector contains (from 5' to 3') a splice acceptor, IRES, Mer-Cre-Mer, a bovine growth hormone 3' UTR, and a Frt-PGKneo-Frt cassette. The MerCreMer double fusion protein has a Cre recombinase cDNA sequence flanked on each end with a mutated murine estrogen receptor (mer) ligand binding domain (amino acids 281-599, G525R); thus rendering Cre expression tamoxifen-inducible yet estrogen-insensitive. (J:101977)
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor     Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  745 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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