Tg(PECAM1-hir/CD4/SELP)#aAdor
Transgene Detail

Summary

• Symbol: Tg(PECAM1-hir/CD4/SELP)#aAdor
• Name: transgene insertion #a, Anthony Dorling
• MGI ID: MGI:5578128
• Synonyms: CD31-Hir-Tg
• Transgene: Tg(PECAM1-hir/CD4/SELP)#aAdor Location: unknown
• Alliance: Tg(PECAM1-hir/CD4/SELP)#aAdor page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human promoter drives expression of the fusion of leech hirudin, domains 3 and 4 of human CD4 domain and intracytoplasmic sequence of human SELP in endothelial cells, monocytes and platelets. Four founders were generated. The unnamed line (#a) contains greater than 30 copies of the transgene. (J:92695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:92695 Chen D, et al., Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood. 2004 Sep 1;104(5):1344-9
• All: 4 reference(s)