Il6^tm1.1Jho
Targeted Allele Detail

Summary

• Symbol: Il6^tm1.1Jho
• Name: interleukin 6; targeted mutation 1.1, Juan Hidalgo
• MGI ID: MGI:5577062
• Synonyms: Il-6^lox
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm1.1Jho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:211914)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 37 strains or lines available

References

• Original: J:211914 Quintana A, et al., Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior. Brain Behav Immun. 2013 Jan;27(1):162-73
• All: 28 reference(s)