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Map3k7tm1.1Gkl
Targeted Allele Detail
Nomenclature
Symbol: Map3k7tm1.1Gkl
Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1.1, George Kollias
MGI ID: MGI:5576979
Synonyms: Map3k7flox
Gene: Map3k7  Location: Chr4:31964097-32023467 bp, + strand  Genetic Position: Chr4, 13.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211916
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2, which encodes part of the kinase domain including the ATP binding pocket. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:211916)
Generation of the Map3k7tm1.1Gkl and Map3k7tm1.2Gkl alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map3k7 Mutation:  34 strains or lines available
References
Original:  J:211916 Eftychi C, et al., Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS One. 2012;7(2):e31550
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory