About   Help   FAQ
Targeted Allele Detail
Symbol: Deaf1tm1.1Mico
Name: DEAF1, transcription factor; targeted mutation 1.1, Michael Collard
MGI ID: MGI:5576138
Synonyms: Deaf12lox, Deaf1fl
Gene: Deaf1  Location: Chr7:141297180-141327690 bp, - strand  Genetic Position: Chr7, 86.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:211699
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
Mutation detailsA loxP site was inserted in intron 1 and a floxed neo resistance cassette was inserted in intron 5. Cre excision of the resistance cassette left exons 2, 3, 4, and 5 flanked by loxP sites. (J:211699)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Deaf1 Mutation:  4 strains or lines available
Original:  J:211699 Vulto-van Silfhout AT, et al., Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems. Am J Hum Genet. 2014 May 1;94(5):649-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory