About   Help   FAQ
Deaf1tm1.1Mico
Targeted Allele Detail
Nomenclature
Symbol: Deaf1tm1.1Mico
Name: DEAF1, transcription factor; targeted mutation 1.1, Michael Collard
MGI ID: MGI:5576138
Synonyms: Deaf12lox, Deaf1fl
Gene: Deaf1  Location: Chr7:141297180-141327690 bp, - strand  Genetic Position: Chr7, 86.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211699
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 1 and a floxed neo resistance cassette was inserted in intron 5. Cre excision of the resistance cassette left exons 2, 3, 4, and 5 flanked by loxP sites. (J:211699)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Deaf1 Mutation:  4 strains or lines available
References
Original:  J:211699 Vulto-van Silfhout AT, et al., Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems. Am J Hum Genet. 2014 May 1;94(5):649-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory