Tg(Thy1-COX8A/Dendra)57Gmnf
Transgene Detail

Summary

• Symbol: Tg(Thy1-COX8A/Dendra)57Gmnf
• Name: transgene insertion 57, Giovanni Manfredi
• MGI ID: MGI:5575873
• Synonyms: mitoDendra, mitoDendra TM57, Thy1-mitoDendra
• Transgene: Tg(Thy1-COX8A/Dendra)57Gmnf Location: unknown
• Alliance: Tg(Thy1-COX8A/Dendra)57Gmnf page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The mitoDendra fusion protein is composed of a cleavable N-terminal mitochondrial targeting pre-sequence (derived from human cytochrome c oxidase subunit VIII [COX8A]), a linker peptide (to improve fusion protein cleavage) and the monomeric photo-activateable fluorescent protein Dendra (derived from octocoral Dendronephthya sp.). The mitoDendra fusion protein cDNA sequence was placed downstream of the modified regulatory region of the "murine thy1.2 gene" (neuronal-specific Thy1.2 promoter; extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns). (J:206221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:206221 Magrane J, et al., Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Hum Mol Genet. 2014 Mar 15;23(6):1413-24
• All: 3 reference(s)