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Transgene Detail
Symbol: Tg(Thy1-COX8A/Dendra)57Gmnf
Name: transgene insertion 57, Giovanni Manfredi
MGI ID: MGI:5575873
Synonyms: mitoDendra, mitoDendra TM57, Thy1-mitoDendra
Transgene: Tg(Thy1-COX8A/Dendra)57Gmnf  Location: unknown  
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
Mutation detailsThe mitoDendra fusion protein is composed of a cleavable N-terminal mitochondrial targeting pre-sequence (derived from human cytochrome c oxidase subunit VIII [COX8A]), a linker peptide (to improve fusion protein cleavage) and the monomeric photo-activateable fluorescent protein Dendra (derived from octocoral Dendronephthya sp.). The mitoDendra fusion protein cDNA sequence was placed downstream of the modified regulatory region of the "murine thy1.2 gene" (neuronal-specific Thy1.2 promoter; extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns). (J:206221)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:206221 Magrane J, et al., Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Hum Mol Genet. 2014 Mar 15;23(6):1413-24
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory