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Targeted Allele Detail
Symbol: Chd5tm1.2Gmbr
Name: chromodomain helicase DNA binding protein 5; targeted mutation 1.2, Garrett M Brodeur
MGI ID: MGI:5575642
Gene: Chd5  Location: Chr4:152338651-152390194 bp, + strand  Genetic Position: Chr4, 83.04 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:207846
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 12. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 13. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 12 and 13. Western blot analysis confirmed the absence of protein expression in the testes. (J:207846)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chd5 Mutation:  37 strains or lines available
Original:  J:207846 Zhuang T, et al., CHD5 is required for spermiogenesis and chromatin condensation. Mech Dev. 2014 Feb;131:35-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory