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n-TRtct5m1J
Spontaneous Allele Detail
Nomenclature
Symbol: n-TRtct5m1J
Name: nuclear encoded tRNA arginine 5 (anticodon TCT); mutation 1, Jackson
MGI ID: MGI:5575489
Synonyms: n-Tr20C57BL/6J, n-TRtct5rs4644711-T, rs46447118
Gene: n-TRtct5  Location: Chr1:173390329-173390402 bp, + strand  Genetic Position: Chr1, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsThis C to T transition, found in C57BL/6J and C57BL/6JEiJ but not other inbred strains, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. (J:211326)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any n-TRtct5 Mutation:  4 strains or lines available
References
Original:  J:211326 Ishimura R, et al., Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science. 2014;345:455-459
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory