Gt(ROSA)26Sor^{tm17(MAP2K7/MAPK8)Jhai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm17(MAP2K7/MAPK8)Jhai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 17, Jody Haigh
• MGI ID: MGI:5575397
• Synonyms: CAJNK1^flox, Gt(ROSA)26Sor^{tm17(JNKK2/JNK1)Jhai}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm17(MAP2K7/MAPK8)Jhai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273281
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A floxed neo/stop cassette and a human cDNA for HA-tagged Map2k7 and Mapk8 (JNKK2-JNK1) fusion followed by an IRES-EGFP were inserted into the locus. The fusion produces a constitutively active protein. (J:273281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:273281 Xu D, et al., MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. PLoS Biol. 2018 Dec;16(12):e2006613
• All: 3 reference(s)