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Piezo2tm2.1Apat
Targeted Allele Detail
Nomenclature
Symbol: Piezo2tm2.1Apat
Name: piezo-type mechanosensitive ion channel component 2; targeted mutation 2.1, Ardem Patapoutian
MGI ID: MGI:5574480
Synonyms: Piezo2-
Gene: Piezo2  Location: Chr18:63010213-63387183 bp, - strand  Genetic Position: Chr18, 35.95 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211312
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was constructed to insert loxP sites upstream of exon 43 and downstream of exon 45 of the Piezo2 gene. The vector contained an frt-flanked PGK-neo cassette upstream of the first loxP site. Following homologous recombination in ES cells, the PGK-neo marker and a single loxP site were upstream of exon 43 and a second loxP site was downstream of exon 45.Chimeric animals were crossed to EIIa-cre expressing mice to delete exons 43-45, causing a frameshift that results in production of a premature stop codon. (J:211312)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Piezo2 Mutation:  5 strains or lines available
References
Original:  J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory