Aspm^tm1.1Kxi
Targeted Allele Detail

Summary

• Symbol: Aspm^tm1.1Kxi
• Name: abnormal spindle microtubule assembly; targeted mutation 1.1, Kyoko Itoh
• MGI ID: MGI:5573151
• Synonyms: Aspm flox
• Gene: Aspm Location: Chr1:139382510-139421829 bp, + strand Genetic Position: Chr1, 61.45 cM, cytoband F
• Alliance: Aspm^tm1.1Kxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205524
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:205524)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspm Mutation: 138 strains or lines available

References

• Original: J:205524 Fujimori A, et al., Disruption of Aspm causes microcephaly with abnormal neuronal differentiation. Brain Dev. 2014 Sep;36(8):661-9
• All: 3 reference(s)