Ighe^tm1Mcdl
Targeted Allele Detail

Summary

• Symbol: Ighe^tm1Mcdl
• Name: Immunoglobulin heavy constant epsilon; targeted mutation 1, Maria A Curotto de Lafaille
• MGI ID: MGI:5573140
• Synonyms: CepsilonGFP, IRES-GFP KI
• Gene: Ighe Location: Chr12:113232883-113236868 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighe^tm1Mcdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208094
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Reporter) Mutation: Insertion Mutation details: An IRES-GFP was inserted between the membrane (M) coding exons and polyadenylation sequence in the 3'UTR. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the first M encoding exon. (J:208094)

Generation of the Ighe^tm1Mcdl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighe Mutation: 24 strains or lines available

References

• Original: J:208094 He JS, et al., The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J Exp Med. 2013 Nov 18;210(12):2755-71
• All: 1 reference(s)